What Are the Benefits of CBD?

//What Are the Benefits of CBD?

What Are the Benefits of CBD?

What Are the Benefits of CBD?

The more CBD success stories you hear, the more it seems like the benefits of this cannabinoid must be too good to be true. You’ve been let down by so-called “miracle cures” in the past, so it’s only natural to be skeptical when a new product is advertised as a panacea.


Cannabidiol isn’t snake oil, however, and the benefits of CBD are based on hard science. While some companies might go over-the-top in describing the potential benefits of this cannabinoid, we like to keep things straightforward here at Nightingale Remedies. No, cannabidiol won’t make you live forever or turn you into an ubermensch. If you have certain serious medical conditions, however, CBD may be able to help when conventional treatments only make things worse.

History of CBD

CBD is a cannabinoid, which means it’s a unique compound that’s only naturally found in the Cannabis sativa plant. While some strains of Cannabis sativa have been bred to be high in THC, others have been bred to be high in CBD. THC-rich cannabis is usually called “marijuana,” and high-CBD cannabis strains are often referred to as “industrial hemp,” “hemp,” or simply “cannabis.”


Like the other cannabinoids, CBD was discovered in the mid-1940s as researchers started looking into the potential medical benefits of cannabis. Early on, scientists determined that CBD exerts potent medical benefits without causing intoxication or the potential of addiction. While THC gained mainstream attention throughout the mid-20th century and beyond, CBD only started capturing the public imagination in the mid-2000s.

The 2014 Farm Bill and Beyond

In 2014, Congress accidentally facilitated the rapid growth of the CBD industry by creating a legal loophole in its new industrial hemp laws. While the 2014 Farm Bill1 was only intended to legitimize pilot hemp research programs operated by the U.S. federal government, the terminology of the bill suddenly made it technically legal to sell CBD-rich products across state lines as long as they contained less than 0.3% THC.


The U.S. government remedied its mistake by passing the Agriculture Improvement Act of 2018 (2018 Farm Bill)2, which removed CBD from the Controlled Substances Act (CSA) and ushered this cannabinoid out of its disconcerting legal gray area. In the intervening years, however, the cannabidiol industry had grown out of control, and the U.S. Food and Drug Administration (FDA) is now struggling to figure out how to deal with the CBD phenomenon.

The Future of CBD

The fact that the FDA hasn’t put a blanket ban on CBD proves that this cannabinoid has at least some medical benefits. While the FDA has approved a pharmaceutical version of cannabidiol for rare types of seizures, it isn’t clear how this federal agency plans to rule on general market CBD.


For consumers, there’s never been a better time to try CBD products. The federal government is now on your side, and it’s even now legal to carry this cannabinoid on the plane for the first time. Major retailers all over the country now carry CBD products, and here at Nightingale Remedies, we ship to all 50 states without fearing legal repercussions.

How Does CBD Work?

CBD works by mediating (controlling) a variety of hormone, endocrine, and neurochemical systems in your body. This cannabinoid mainly exerts its effects by boosting the endocannabinoid system, which is a natural cannabinoid-processing system that controls biological factors like metabolism and mental health.


Unlike THC, CBD doesn’t directly stimulate the CB1 and CB2 receptors, which are the main neurochemical components of the endocannabinoid system. Instead, it appears to boost the activity of the 5-HT1A3, TRPV14, and GPR555 receptors along with a variety of other bodily systems. The 5-HT1A receptors are involved in depression, anxiety, and psychosis, and the TRPV1 receptors are involved in pain, epilepsy, and inflammation.


The GRP55 receptors, on the other hand, are involved in gene expression and cancer, which is why medical researchers are keenly interested in the potential of CBD as an anti-cancer drug. Everywhere you look, cannabidiol appears to improve your health by stimulating vital regulatory systems in the body. The best part? CBD doesn’t have any major side effects.

Top 7 Benefits of CBD

Over the years, scientists have discovered a variety of potential benefits of CBD, and as interest in this cannabinoid increases, research into this cannabinoid is rapidly ramping up. Researchers have discovered dozens of potential benefits of cannabidiol, but here at Nightingale Remedies, we think that these seven CBD benefits are some of the most important to know about:

1. CBD for Inflammation and Oxidative Stress

A variety of studies have indicated that cannabidiol reduces inflammation and oxidative stress6. The importance of this discovery can’t be overstated; oxidative stress is the main cause of telomere degeneration7 and cell replication problems, which contributes to aging. Additionally, inflammation is the main cause of pain, and some researchers even believe that inflammation may be the root cause of all disease and illness8. Since CBD appears to exert more powerful antioxidant properties than either vitamin C or vitamin E, there seems to be no limit to the therapeutic potential of this non-intoxicating cannabinoid.

2. CBD for Depression

As we mentioned earlier, CBD appears to act as an agonist (activator) at the 5-HT1A receptors in your brain. Also known as the serotonin 1A receptor, the 5-HT1A receptor is the most abundant serotonin receptor in your body, and decreased levels of serotonin in your brain can lead to depression.


Serotonin is critically involved in the feelings of pleasure and reward, and depression is typified by a disinterest in pleasure-inducing activities. Severe forms of depression can result in catatonia or suicide. By directly stimulating the 5-HT1A receptors9, cannabidiol appears to make your brain think it has more serotonin than it actually does, and it also seems that CBD actually increases the levels of serotonin and glutamate10 in your brain. Glutamate deficiency is another contributing factor to depression.

3. CBD for Anxiety

Depression and anxiety aren’t that different from a neurochemical perspective. Both psychiatric conditions are caused by decreased 5-HT1A activation in the brain, which means that cannabidiol’s reported action as a 5-HT1A agonist should help with anxiety as well. Research has confirmed that CBD appears to reduce anxious behaviors in rats11, and human studies have found that CBD seems to reduce the symptoms of social anxiety12.


By directly stimulating the reward circuits in your brain, CBD appears to bypass the mechanisms that support both depression and anxiety. Over time, the reduction in anxious or depressive symptoms may result in an overall increase in mental well-being even after the cessation of CBD therapy. Individuals suffering from anxiety might benefit from keeping fast-acting CBD products on them at all times and supplementing with oral CBD.

4. CBD for Cancer

CBD proponents have gotten a lot of flack for hawking this cannabinoid as a cancer cure. While it would be a stretch to say that cannabidiol can and will cure cancer every time, there’s no denying that this cannabinoid appears to have potent anti-cancer properties that have been confirmed by multiple independent studies13.


Instead of just saying, “CBD might cure cancer,” and leaving it at that, it’s important to take a look at how research indicates cannabidiol might inhibit certain specific mechanisms that promote the onset and progression of cancer. For instance, it seems that CBD prevents angiogenesis14, which is a technical term for the formation of cancer tumors.


Additionally, CBD appears to prevent the proliferation of cancer cells15, which is how cancer spreads throughout your body. While research into cannabinoids and cancer is admittedly still in its infancy, it even seems that the endocannabinoid system itself plays a key role in preventing cancer16. Since cannabidiol appears to boost the action of the endocannabinoid system, this cannabinoid’s apparent cancer-fighting functions may have a surprisingly simple explanation.

5. CBD for Acne

Since acne is an inflammatory condition17, common sense would dictate that CBD’s apparent anti-inflammatory and antioxidant functions would reduce the symptoms of this disfiguring skin condition. Hemp researchers didn’t stop there, however; a wide body of research18 has been conducted to get to the bottom of cannabidiol’s benefits for acne.


For instance, it appears that CBD reduces inflammation in the sebocytes19, which are the sebum-producing glands that can clog your pores when they become overactive and inflamed. Additionally, research suggests that when your endocannabinoid system is healthy, your skin is healthy too20. Therefore, cannabidiol’s reported endocannabinoid-boosting effects may improve your skin health in every way imaginable. If you want to enjoy the skin benefits of cannabidiol to their fullest, you might consider trying a water-based topical CBD product.

6. CBD Oil for Sleep

We’ll be straight with you: The studies that have been conducted to directly take a look at how cannabidiol affects sleep have been inconclusive. While some animal studies appear to indicate that CBD helps you sleep better and for longer21, other research shows that CBD might increase alertness22. If you take these limited studies at face value, however, you’re missing the big picture.


What are the main things that keep you from going to sleep at night? If you’re like most people, you’ll list pain and anxiety as the main culprits. Well, what have we learned about cannabidiol so far? Two of this cannabinoid’s main benefits appear to be pain reduction and anxiety relief. If your diabetic neuropathy or crippling anxiety are keeping you awake, a CBD capsule an hour before bed might be just what you need to get a good night’s sleep.

7. CBD Oil for Migraines

In addition to mediating depression and anxiety, the serotonin system also plays a key role in the development of migraines. These crippling headaches are usually caused by decreased serotonin levels in your brain, but conventional pharmaceutical treatments designed to artificially increase serotonin to fight migraines have crippling side effects.


Scientists are just now looking into the benefits of CBD oil for migraines23 specifically, but if our knowledge about CBD’s action at the 5-HT1A receptors is any guide, it’s clear that the potential of cannabidiol as a safe, potent anti-migraine treatment shouldn’t be overlooked.

Benefits of CBD Oil: The Bottom Line

If there’s one thing that makes you look like a shady snake oil salesman, it’s making unsubstantiated claims about your products. That’s why the FDA serves such a vital function; this agency makes sure that only legitimate products make their way into the market, and we welcome FDA regulatory action on cannabidiol when and if it ever arrives.


Until that day, Nightingale Remedies will continue to separate itself from the competition by providing hard scientific evidence on the benefits of CBD. We’ll never claim that cannabidiol will cure your cancer to make a quick buck. What we will do, however, is point you toward the studies indicating that CBD has anti-cancer benefits and leave it up to you to come to a conclusion.


The discovery of cannabidiol as a healing tool is one of the most exciting developments in the history of natural medicine. Cannabis has been used for medicinal purposes for thousands of years, but it’s only in the modern scientific era that human ingenuity has unlocked the secrets of this potent plant ally for the first time.


While it could be said that cannabidiol research is still in its infancy, we already know so much, and millions of people around the world have benefited from using this side-effect-free, non-intoxicating cannabis derivative. Experts expect that the CBD market will grow to a $20-billion-per-year industry by 202424, which is a powerful testament to this cannabinoid’s enduring popularity.


No matter what the future may bring, Nightingale Remedies will remain your trusted source for all things CBD. From the latest cannabidiol news to the highest-quality CBD products on the market, count on us to deliver exactly what you need to stay informed and healthy.


Questions? Reach out to us anytime for a prompt reply.


  1. H.R.2642 – Agricultural Act of 2014
  2. H.R.2 – Agriculture Improvement Act of 2018
  3. Agonistic properties of cannabidiol at 5-HT1a receptors.
  4. Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
  6. Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
  7. Oxidative stress shortens telomeres.
  8. The inflammation theory of disease
  9. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors
  10. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors
  11. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.
  12. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
  13. Cannabidiol as potential anticancer drug
  14. Cannabidiol inhibits angiogenesis by multiple mechanisms
  15. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
  16. The current state and future perspectives of cannabinoids in cancer biology
  17. The Role of Inflammation in the Pathology of Acne
  18. Cannabidiol as a Treatment for Acne?
  19. Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
  20. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities
  21. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
  22. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
  23. Emerging Role of (Endo)Cannabinoids in Migraine
  24. CBD Market Could Reach $20 Billion By 2024, Says New Study
By |2019-07-18T22:46:14+00:00July 16th, 2019|Categories: Uncategorized|1 Comment

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